Functional characterisation of a new regulatory mechanism for CaMKII at synapses in vivo

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/455534

Funding Status
Closed

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Funded Activity Summary

CaMKII is an important regulatory molecule in the brain where it plays an essential role in certain forms of learning and memory and in the appropriate development and maturation of neural pathways and undergoes specific changes in animal models of brain ischaemia and epilepsy. Recent evidence has shown that, in nerve cells, the regulation and role of CaMKII is more complicated than previously thought. This project will investigate the roles of a new control mechanism in regulating the function of CaMKII in nerve cells. The experiments will involve an international team of collaborators using cutting edge techniques at the molecular, cellular and whole animal level. This will provide a more complete understanding of how CaMKII influences brain function and allow an assessment of whether CaMKII regulation might be a suitable target for drugs aimed at protecting against the damaging effects of brain injury following stroke or heart attack.

Funded Activity Details

Start Date: 01-01-2007

End Date: 01-01-2009

Funding Scheme: NHMRC Project Grants

Funding Amount: $547,315.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cell Neurochemistry

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

cell signalling | cerebral ischaemia | cortical plasticity | learning | molecular basis of disease | neuroprotective drugs to minimise neural death after stroke | neurotransmission | protein phosphorylation | synaptic plasticity

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