Optimal duration of neoadjuvant androgen deprivation therapy in localised prostate cancer treated by radiotherapy

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/455520

Funding Status
Closed

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Funded Activity Summary

The 96.01 trial aims to find out whether androgen deprivation (AD) administered prior to and during radiotherapy (i.e., neo-adjuvant AD) will improve outcomes in patients with locally advanced prostate cancer that is considered inoperable and is treated for cure by radiotherapy. The trial also aims to find out whether six months AD produces outcomes superior to those achieved by three months AD. The trial has been running since 1996 and involves 802 men who attend 19 cancer treatment centres across Australia and New Zealand. It would not have been possible without the continuous funding support of the NHMRC. So far this trial has shown that AD does prevent prostate cancer from returning after radiotherapy. This is very important because the need for treatment of recurrent cancer (usually AD for the rest of the patient's life) is halved by 6 months AD compared to standard treatment (radiotherapy alone). However, it is now necessary to observe the patients in this trial for another 5 years to find out whether AD also prolongs life, and whether 6 months AD is more effective than 3 months. Further patient follow up is also necessary to identify whether some men respond better to treatment than others. This is very important because it will enable treatment to be tailored to individual patients, in particular those who require more treatment than is given in this trial. This funding application is therefore to enable patient follow up on this large scale trial for another 5 years.

Funded Activity Details

Start Date: 01-01-2007

End Date: 01-01-2012

Funding Scheme: Project Grants

Funding Amount: $422,335.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Oncology And Carcinogenesis

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

clinical trial | endocrine therapy | metastases | prostate cancer | prostate cancer metastasis | prostate carcinoma-RT (Radiotherapy) | quality of life | radiotherapy | radiotherapy-adverse events

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