Inflammation-associated S100 proteins: links between arthritis and atherosclerosis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/455306

Funding Status
Closed

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Funded Activity Summary

Deeper understanding of the basic contributions of inflammation to cardiovascular disease can lead to better strategies for treatment and diagnosis. There are shared mechanisms in rheumatoid arthritis and these patients are at significantly higher risk of myocardial infarction and heart failure than the healthy normal population. This project will improve heart health because it will address how newly-recognised proteins, called S100 proteins, mediate pathogenesis and how they are regulated in cells by various therapeutic drugs. We developed a potential diagnostic test that distinguishes patients with angina from those with arthritis and this could be useful in improving diagnosis and following treatment of patients with cardiovascular disease or arthritis. We find that some anti-inflammatory drugs enhance S100 gene expression whereas our preliminary data indicates that some cholesterol-lowering drugs (statins) reduce it. Results of treating patients with arthritis with statins will add to understanding of why cholesterol-lowering drugs commonly used in management of CVD patients may be effective in treating symptoms in arthritis sufferers and could contribute to changes in clinical management of these patients.

Funded Activity Details

Start Date: 01-01-2007

End Date: 01-01-2009

Funding Scheme: NHMRC Project Grants

Funding Amount: $454,691.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Rheumatology and Arthritis

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Chronic inflammation: rheumatoid arthritis, atherosclerosis | Inflammatory mediators and S100 proteins | anti-inflammatory drugs | cardiovascular and other disease prevention | corticosteroids and anti-inflammatory drugs | development of diagnosis and treatment regimes | diagnosis | immunomodulation | immunoregulation | protein oxidation

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