A randomised trial of surgery versus surgery plus radiotherapy for regional control in patients with stage 3 melanoma

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/454745

Funding Status
Closed

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Funded Activity Summary

Melanoma is a common disease in Australia. When it has spread to lymph glands it has a poor prognosis. If not controlled it can lead to severe local symptoms including pain, bleeding and disabilty. This is a world first clinical trial involving radiotherapy given after surgery for melanoma involving regional lymph glands. It involves a head to head comparison of surgery alone versus surgery followed by radiotherapy. The target is 230 patients, more than 160 being so far recruited. The main outcome of the study is control of melanoma in the lymph gland basin. Other outcomes are survival, time to recurrence, side-effects (such as lymphoedema) and quality of life. The trial currently involves 13 centres in Australia, New Zealand and the Netherlands. It is expects to be completed in 2007.

Funded Activity Details

Start Date: 01-01-2007

End Date: 01-01-2009

Funding Scheme: NHMRC Project Grants

Funding Amount: $305,163.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Radiation Therapy

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

Lymphoedema | Melanoma | Quality of life | Radiation Biology | Radiotherapy | Randomised controlled trial | Surgery

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