Physiology of a mutant angiotensin receptor associated with cardiac hypertrophy

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/454626

Funding Status
Closed

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Funded Activity Summary

As many as one in ten healthy individuals have hearts that are bigger than normal. Careful scientific investigation has revealed that the bigger one's heart, the greater the risk of dying from cardiovascular disease. This is true even in the absence of known causes of heart disease. Unlike high blood pressure or cholesterol, the size of the heart is not easily measured and enlargement often goes undetected. We were among the first internationally to discover genetic clues to enlarged hearts. We identified a region on a rat chromosome that influences heart size and we have now discovered abnormalities in a key gene in this region. These changes alter the function of a cellular protein that mediates hormonal effects on heart cell size. Our team of experts will employ the most modern technologies to understand exactly how this altered protein affects heart cell function and growth. We have a unique opportunity to exploit this experiment of nature to help us devise new means of preventing big hearts and their fatal complications in humans.

Funded Activity Details

Start Date: 01-01-2007

End Date: 01-01-2008

Funding Scheme: NHMRC Project Grants

Funding Amount: $293,699.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cardiology (incl. Cardiovascular Diseases)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Angiotensin | Angiotensin receptor antagonists | Cardiac hypertrophy | Cell biology | Coronary heart disease | Heart failure

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