Can exercise and improved nutrition normalise rat skeletal muscle mitochondrial biogenesis following growth restriction?

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/454570

Funding Status
Closed

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Funded Activity Summary

Being born small is associated with the development of adult diseases such as insulin resistance, cardiovascular disease and type 2 diabetes. Mitochondria are responsible for generating energy within all cells and impaired mitochondrial function is implicated in the development of these diseases. We have exciting preliminary data demonstrating that being born small impairs the synthesis of mitochondria in adult rat skeletal muscles. This project will determine if lifestyle interventions such as exercise and improved nutrition after birth in rats that were born small can normalise the molecular signals responsible for mitochondrial synthesis in muscle. Understanding these mechanisms responsible for mitochondrial function will provide insight into early life interventions that may lessen the adverse consequences of being born small. This research will increase the likelihood that practical public health interventions can be developed to improve adult health.

Funded Activity Details

Start Date: 01-01-2007

End Date: 01-01-2009

Funding Scheme: NHMRC Project Grants

Funding Amount: $338,128.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Foetal Development and Medicine

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

Fetal growth retardation | Fetal origins of adult disease | diabetes-exercise | exercise training | insulin resistance | mitochondria | nutrition | skeletal muscle

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