SPARC and SPARC cluster genes in tumourigenesis.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/454557

Funding Status
Closed

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Funded Activity Summary

Expression profiling of many cancers has revealed a common signature, including upregulation of SPARC and other extracellular matrix proteins (the SPARC cluster), which correlates with poor prognosis. This signature is similar to the wound healing gene expression profile after infection by the parasite, Leishmania. Moreover, genomic regions important for differences in the wound healing response in mice have been defined that may define novel genes important for regulating SPARC cluster gene expression. However, these regions contain 1000s of genes , and thus to define the critical genes other approaches are neccesary. The genetically manipulable animal model, Drosophila (vinegar fly), represents a ideal system to detect SPARC interacting genes that should help define the critical genes that regulate SPARC cluster genes. These regulators that trigger SPARC cluster gene expression are likely to define novel cancer causing genes.

Funded Activity Details

Start Date: 01-01-2007

End Date: 01-01-2009

Funding Scheme: NHMRC Project Grants

Funding Amount: $503,428.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Oncology and Carcinogenesis

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

Drosophila melanogaster models of cancer | Extracellular matrix | cancer and related disorders | cancer; mechanims of growth, invasion and metastasis | cell adhesion | mouse models of cancer | tumour microenvironment

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