Respiratory modulation of RVLM premotor neurons: role in the sympathetic over-activity of hypertension.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/454432

Funding Status
Closed

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Funded Activity Summary

Hypertension is a common health disorder in all societies and is a major risk factor for the development of life threatening cardiovascular diseases, including heart failure and stroke. Whilst some effective therapies are available, many patients are not adequately treated or have reduced quality of life due to serious side effects. There is a great need for alternative therapies. The central nervous system is clearly involved in hypertension although the level of that involvement is not well understood- i.e. is it a causal factor or just a contributor to the maintenance of established hypertension? The experiments outlined in this application are based on the observation that modulation of nervous activity to blood vessels is more influenced by the respiratory system in people with high blood pressure, than in normotensive people. We aim to test whether this increased respiratory modulation might be involved in the generation of the high blood pressure.

Funded Activity Details

Start Date: 01-01-2007

End Date: 01-01-2009

Funding Scheme: NHMRC Project Grants

Funding Amount: $338,605.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Autonomic Nervous System

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

blood pressure | blood pressure regulation | cardiorespiratory control | cardiovascular disease and hypertension | central autonomic control | sympathetic nervous system

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