An integrated analysis of gene expression and chromosome copy number in malignant mesothelioma

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/454407

Funding Status
Closed

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Funded Activity Summary

Mesothelioma is an aggressive, asbestos related cancer which causes more than 20,000 deaths worldwide per annum. Mesothelioma is characterised by a long latency between exposure to asbestos and development of the disease, estimated to be between 20 and 40 years. As such, the peak number of cases of mesothelioma is not expected in Australia until 2010, as asbestos use reached its peak in the 1970-80's. In 2010, deaths from mesothelioma will be more common than ovarian cancer and melanoma. This study aims to explore the molecular defects that are involved in initiation and progression of mesothelioma. Using array comparative genomic hybridisation, a technique which allows comparison of the DNA of normal cells with that of cancer cells, we will classify chromosomal changes in the cancer cell and identify candidate genes which are involved in mesothelioma development.

Funded Activity Details

Start Date: 01-01-2007

End Date: 01-01-2011

Funding Scheme: Targeted Calls

Funding Amount: $421,697.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Other biomedical and clinical sciences not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Oncogenesis | mesothelial cells | mesothelioma | microarray | respiratory diseases

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