The impact of developmental haemostasis on the pharmacokinetics and pharmacodynamics of heparin in children.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/454385

Funding Status
Closed

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Funded Activity Summary

Unfractionated Heparin (UFH) is the most commonly used anticoagulant (blood thinning drug) in children. Despite this, the clinical evidence, in terms of reported treatment failures and bleeding complications, suggests the drug is used suboptimally in children compared to adults.This likely relfects the lack of specific studies of UFH in children. This study will, for the first time, define the pharmacokinetics-dynamics of UFH in children, allowing age-specific protocols to be developed. Pharmacological modelling of this data will likely have implications for the use of other anticoagulants in children.

Funded Activity Details

Start Date: 01-01-2007

End Date: 01-01-2009

Funding Scheme: NHMRC Project Grants

Funding Amount: $283,676.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Paediatrics

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Anticoagulation | Children | Clinical Pharmacology | Developmental Haemostasis | Paediatrics | Pharmacotherapy

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