Understanding the function of the CCR7 chemokine receptor in breast cancer cells and tumours.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/453612

Funding Status
Closed

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Funded Activity Summary

As much as 90% of cancer related deaths occur due to the development of metastatic tumours, and to be able to develop efficient therapies for malignant cancers it is necessary to uncover and study in detail the specific characteristics that allow cancer cells to disseminate from the site of primary tumour. Recent work has implicated proteins that regulate cell movment known as chemokines in this process. We wish to identify and understand the mechanisms by which breast cancer cells use chemokines and their receptors, molecules normally employed by blood cells, to promote tumour metastasis to specific anatomical sites with a view to identify novel targets for therapeutic intervention and risk assessment in breast cancer

Funded Activity Details

Start Date: 01-01-2007

End Date: 01-01-2009

Funding Scheme: NHMRC Project Grants

Funding Amount: $549,446.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Oncology and Carcinogenesis

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

breast cancer | cancer biology | chemokine | metastasis | murine model | signal transduction | tumourigenesis

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