Which transgenic pig will be used for islet transplantation in humans?

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/447718

Funding Status
Closed

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Funded Activity Summary

We propose that xenotransplantation of pig islets will cure Type 1 diabetes. This program will generate genetically modified pigs to overcome the molecular differences between pigs and humans by removing a pig gene and inserting several human genes. In addition, we will add immunosuppressive genes and so minimise the need for drug treatment of the diabetic recipient. We will test our hypothesis by transplanting islets from these genetically modified pigs into baboons. We suggest that this will provide an inexhaustible supply of islets for transplantation.

Funded Activity Details

Start Date: 01-01-2007

End Date: 01-01-2013

Funding Scheme: NHMRC Strategic Awards

Funding Amount: $3,031,083.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Endocrinology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Diabetes | Islets | Transgenics | Transplantation | Xenotransplantation

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