NEW INSIGHTS INTO THE FUNCTION OF SERPINB2

Funded Activity Summary

Plasminogen activator inhibitor type 2 (PAI-2) or SerpinB2 is a protein that has been extensively studied in the field of cancer prognosis and inflammation. Although it is widely believed that this protein exists outside the cell and inhibits enzymes involved in blood clotting and cell migration, it is becoming increasingly clear that this may not be its primary function. We have identified two important new functions for this protein that are related to activities within the cell. These activities involve regulation of cellular growth and resistence to viral infections. This grant seeks to characterise these different activities and determine how they affect cell behaviour and thereby determine the real role of this protein. Understanding what this protein actually does will have implications for understanding cancer prognosis and antiviral resistance.

Funded Activity Details

Start Date: 01-01-2007

End Date: 01-01-2009

Funding Scheme: NHMRC Project Grants

Funding Amount: $513,946.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Biochemistry: Proteins and Peptides (incl. Medical Proteomics)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

anti-viral immunity | cancer biology | cancer prognosis | cell cycle | innate immunity | malignant tumour growth | monocyte/macrophage | post translational protein regulation | protease inhibition | serpin

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