Mechanisms and Regulation of ACE2 Shedding

Funded Activity Summary

High blood pressure and heart disease, are a significant health issue affecting more than 25% of the Australian population. We have recently found that a new enzyme called ACE2 involved in cardiovascular regulation is greatly increased in heart tissue following heart attack. Furthermore, we have evidence that this enzyme is released into the blood after a heart attack or as a consequnce of chronic liver injury. The current project aims to expand on our preliminary data and to understand the basic biology underlying the mechanism of ACE2 secretion in cardiovascular and liver diseases. In addition, the measurement of ACE2 in plasma may provide useful information on prognosis and knowledge of the mechanism underlying ACE2 secretion may define new therapeutic targets to treat and prevent cardiovascular and liver disease

Funded Activity Details

Start Date: 01-01-2007

End Date: 01-01-2008

Funding Scheme: NHMRC Project Grants

Funding Amount: $239,017.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cardiology (incl. Cardiovascular Diseases)

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

Chronic Liver Disease | Ectodomain Shedding | Enzyme regulation | Ischemia | Protease | cardiovascular disease | renin angiotensin system

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