A novel CD39-like ecto-NTPDase of Legionella pneumophila

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/436607

Funding Status
Closed

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Funded Activity Summary

Legionnaire's disease is a serious cause of community acquired pneumonia. We are studying the way the Legionella bacteria persist in the environment and cause disease. We have found that Legionella produces a specific protein that mimics the action of a human protein. This proposal aims to work out how the bacteria use this protein to infect the human lung and escape killing by immune cells. The results from this study will help to determine if this protein may be used as a target for the development of new anti-infective drugs.

Funded Activity Details

Start Date: 01-01-2007

End Date: 01-01-2009

Funding Scheme: NHMRC Project Grants

Funding Amount: $362,046.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Bacteriology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Bacterial pathogen | Bacterial virulence factors | Community aquired infection | Host-pathogen interaction | Legionella | Legionnaire's disease | Pneumonia

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