Single Molecule Cell Biology

Funded Activity Summary

Our current understanding of cellular signalling and disease is based on ensemble measurements over a cellular or molecular population. While these measurements have provided valuable information on the molecular circuitry required for cellular function, there is a lack of detail on the spatio-temporal dynamics of signal initiation and propagation at the single molecule and single cellular level. Single particle (molecule or cell) approaches offer the advantage of being able to detect individual processes including rare events that would be lost in an ensemble measurement. Moreover single particle approaches provide dynamic-kinetic information that does not rely on synchronising a population of molecules or cells. In this proposal we aim to build on our combined expertise in EGF-EGFR signalling, biophysics, biosensors, quantum dot nanotechnology and single molecule spectroscopy to learn more about how EGFR cellular signalling works and how it is impaired in cancer. This project will provide basic information that could lead to the design of more effective drugs directed agaisnt this therapeutic target.

Funded Activity Details

Start Date: 01-01-2007

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $297,038.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Analytical Biochemistry

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

biochemistry | biological sciences | biotechnology | cancer biology | epidermal growth factor receptor | epithelial neoplasms-malignant | growth factors-receptors | quantum dots | ratio fluorescence spectroscopy | single molecule spectroscopy

Related Links