Expansion of TGF-beta-Smad signaling network and intrinsic epithelial-mesenchymal-endothelial transition

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/433619

Funding Status
Closed

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Funded Activity Summary

The majority of tumor death occurs due to tumor metastasis. Both tumor growth and tumor spread require angiogenesis, which is thought to be driven by tumor but originated from host endothelial cells. Could tumor cells behave and function like endothelial cells? This application aims to detect the transition of adult epithelial cells to endothelial cells through a transient mesenchymal state. Our studies should reveal both the molecular and cellular causes of vasculogenic mimicry, thus establishing a new paradigm in understanding tumor growth and metastasis. Such novel molecular understanding will open up new anti-tumor therapeutic opportunities.

Funded Activity Details

Start Date: 01-01-2007

End Date: 01-01-2010

Funding Scheme: Project Grants

Funding Amount: $557,297.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cell Development, Proliferation and Death

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Angiogenesis | Carcinogenesis | Cell biology | Epithelial-mesenchymal-endothelial transition | Signal transduction | TGF-b-Smad signaling | Vasculogenic mimicry | tumor metastasis

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