Role of load detection and compensation in pathogenesis of obstructive sleep apnea.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/430300

Funding Status
Closed

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Funded Activity Summary

This proposal will use novel techniques to explore how defective responses to the threat posed by a collapsing upper airway contribute to the Obstructive Sleep Apnea syndrome, a disease involving repetitive collapse of the upper airway in sleep. Responses to small increases in the resistance to inspiratory airflow will be examined by measuring the small electrcal responses in the brain to these loads, and the response of the muscles responsible for maintaining airway patency to the collapsing forces induced by these loads, in both wakefulness and sleep. The brain's response to resistive loads will also be evaluated using the techique of functional magnetic resonance imaging, which demonstrates areas of the brain activated by a stimulus.

Funded Activity Details

Start Date: 01-01-2007

End Date: 01-01-2010

Funding Scheme: Project Grants

Funding Amount: $340,867.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Respiratory Diseases

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Sleep Apnea | neural reflexes | neuroimaging | obstructive sleep apnea | pathogenic mechanisms | respiratory control | respiratory diseases

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