Molecular and cellular studies of the adaptive immune response in health and disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/427620

Funding Status
Closed

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Funded Activity Summary

Immune responses protect us against pathogens such as viruses and bacteria. However inappropriate immune responses can result in autoimmune conditions such as systemic lupus erythmatosus, multiple sclerosis, type I diabetes, asthma as well as immunodeficiencies. The aim of our proposal is to gain a thorough understanding of how all the cells of the immune system function and interact with each other, and what goes wrong when inflammatory diseases develop. We plan to do this using state-of-of-the-art technologies, including genetically modified mice, gene microarrays, monoclonal antibodies, and flow cytometry. We have brought together Australia's leading immunologists with complimentary expertise and research interests in specific areas of immunology including cytokines, cell migration, inflammatory diseases, autoimmunity and cell-cell interactions. One aspect of the application is to understand the genetic and molecular basis of immunological diseases. However we also wish to move on from an understanding to treatment of immunological diseases through the development of novel therapeutics. We will form collaborations with biotech and pharmaceutical companies (including our own spin off companies) to advance important new therapeutics for autoimmune and allergic diseases. These conditions represent a significant health burden to Australia.

Funded Activity Details

Start Date: 01-01-2007

End Date: 01-01-2011

Funding Scheme: Programs

Funding Amount: $16,509,154.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Autoimmunity

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

Autoimmune initiation | Autoimmunity | Immune dysfunction | Inflammation | Inflammation and inflammatory joint disease | autoimmune diseases | cytokines and chemokines | immune responses | immunlogical tolerance | immunorgulation

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