Role of heparan sulfate, heparanase inhibitors in the development and prevention of type 1 diabetes

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/418138

Funding Status
Closed

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Funded Activity Summary

Our recent studies have shown that a special protein (an enzyme called heparanase) and the special carbohydrate (heparan sulfate or HS) that it degrades, play a previously unrecognised role in the development of Type I diabetes (T1D) in mice. We will explore whether destructive immune cells use heparanase to damage insulin-producing islets and deplete them of HS, resulting in islet cell death and T1D. We will develop new agents to inhibit this damage, prevent T1D and protect islet transplants.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2013

Funding Scheme: NHMRC Strategic Awards

Funding Amount: $3,242,772.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Autoimmunity

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Autoimmune diabetes | Diabetes prevention | Enzyme inhibitors as pharmacological agents | Extracellular matrix | Transplantation and graft rejection

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