Transcriptional Regulation and the role of key histone variants in defining gene-specific chromatin states.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/418076

Funding Status
Closed

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Funded Activity Summary

One of the most outstanding and significant questions within this genome era has been to unravel how chromatin structure within the nucleus of a cell is capable of regulating the complex expression patterns needed for cell proliferation, cell differentiation and cellular responses to environmental factors such as pathogens and signaling molecules. Studies on lower eukaryotes have demonstrated that deposition of histone variants provides a powerful mechanism for modulating chromatin structure. To date, there is no comprehensive picture of the contribution of histone variants in the transcriptional process in higher eukaryotes. Preliminary results obtained in our laboratory have provided fascinating first insights into the role of key histone variants in the control of regulatory regions of key genes involved in the immune system. Importantly, these results have enabled us to identify a novel chromatin regulatory mechanism that this proposal aims to investigate in necessary detail. The outcome of the proposed research will give an in depth understanding on how chromatin structure is influenced by the recruitment of histone variants and how this mechanism is crucially involved in gene regulation. Crucially, we will attempt to answer some of the most outstanding and significant questions about how chromatin dynamics within the nucleus switch on-off a defined subset of genes in response to a particular environmental stimulus. In addition, the new level of understanding of the events in metastasis-invasion will help provide advances in cancer and gene therapy.

Funded Activity Details

Start Date: 01-01-2007

End Date: 01-01-2009

Funding Scheme: NHMRC Project Grants

Funding Amount: $450,696.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Gene Expression (incl. Microarray and other genome-wide approaches)

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

Biochemistry and Molecular Biology | T cell immunity | T cells | T lymphocyte response | chromatin structure | epigenetics | gene expression | gene regulation | transcriptional regulation

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