Screening agents active against the late-stage inflammatory cytokines for activity against influenza disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/410222

Funding Status
Closed

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Funded Activity Summary

Infection with a virulent influenza virus that the body has never encountered before, particularly H5N1, sends the immune system into overdrive, and causes a massive release of proteins (inflammatory cytokines), known as a cytokine storm, that in and of itself leads to death. The object of this research is to screen, in a mouse influenza model, agents known to prevent this occurring and antagonise it once it has occurred. This will be done with and without Tamiflu, a standard anti-influenza drug.

Funded Activity Details

Start Date: 01-01-2006

End Date: 01-01-2008

Funding Scheme: NHMRC Strategic Awards

Funding Amount: $241,409.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Infectious Diseases

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Antiviral Drug Resistance | Inflammatory Cytokines | Influenza Illness | Prevention | Treatment

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