Sensitive, rapid and accurate detection of the emergence of neuraminidase inhibitor resistance by real-time PCR, LCR and

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/408114

Funding Status
Closed

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Funded Activity Summary

An influenza pandemic causing by highly pathogenic H5N1 virus may occur in the near future. As a vaccine for H5N1 will not be available in the foreseeable months, antiviral drugs are the only possible choice for prophylaxis and treatment. Currently only two drugs have been clinically proven to be effective against H5N1 strain and the emergence of drug resistant in H5N1 influenza virus has been reported which may significantly hamper the treatment. Understanding and monitoring the emergence of these drug resistant strains during local spreading will be critical in managing an H5N1 influenza pandemic in Australia. In the proposed project, we will develop important diagnostic tools using our world leading Rolling Circle Amplification (RCA) technology for the monitoring of the development and possible transmission of drug resistant influenza strains. Upon finishing the project, at lease three sensitive diagnostic methods will be developed for the detection of the emergence of drug resistance at the very early stage.

Funded Activity Details

Start Date: 01-01-2006

End Date: 01-01-2006

Funding Scheme: NHMRC Strategic Awards

Funding Amount: $118,875.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Infectious Diseases

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Antiviral | Drug resistance | Genetic testing | Infection | Influenza

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