Investigation of the localisation, transport and vaccine potential of group A streptococcal cell surface proteins.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/404502

Funding Status
Closed

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Funded Activity Summary

Streptococcus pyogenes (group A streptococcus; GAS) is a bacterium that causes human skin and throat infections as well as highly invasive diseases including necrotising fasciitis. Additionally, serious sequeale, including rheumatic fever and acute glomerulonephritis, may result following repeated infection. We have recently examined the GAS cell wall and identified 23 proteins that are surface exposed, 20 of which are novel. We hypothesise that a number of these surface exposed proteins represent candidate vaccine antigens capable of conferring protective immunity. We therefore propose to examine these surface proteins as components of experimental vaccines against GAS.

Funded Activity Details

Start Date: 01-01-2006

End Date: 01-01-2008

Funding Scheme: NHMRC Project Grants

Funding Amount: $505,523.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Bacteriology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Streptococcus pyogenes | acute post-streptococcal glomerulonephritis | cell surface | necrotising fasciitis | pharyngitis | rheumatic fever | streptococcal infection | vaccine

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