Congestive heart failure: a longitudinal study of its impact on brain function and structure in later life.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/403996

Funding Status
Closed

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Funded Activity Summary

This project aims to clarify the long-term impact of congestive heart failure (CHF) on brain function and structure. CHF is a common complication of most diseases of the heart, with over 30,000 new cases being diagnosed annually in Australia. Of all CHF hospitalisations, 75% are made up of people aged 70 years or over. Consequently, as the Australian population ages, the number of people with CHF is expected to rise sharply. CHF is associated with increased mortality and significant morbidity. It also impacts upon quality of life in other ways. The daily life of patients is often limited by the direct effects of CHF, such as exertional dyspnoea, fatigue and weakness; associated medical conditions, such as ischaemic heart disease, hypertension and diabetes, as well as depression and memory impairment. Of note, cognitive impairment is a leading cause of years of life lost due to disability in Australia. This project aims to clarify the factors that contribute to the development of cognitive deficits in people with CHF. Its results should serve as a basis for the development of effective preventative strategies to halt or slow down the development of such deficits. In addition, we expect that the findings of the study will improve our understanding of other common disorders associated with cognitive decline in later life, such as Alzheimer's disease.

Funded Activity Details

Start Date: 01-01-2006

End Date: 01-01-2008

Funding Scheme: NHMRC Project Grants

Funding Amount: $612,130.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Geriatrics and Gerontology

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

aged | brain imaging | cardiovascular and peripheral vascular disease | congestive heart failure | heart disease in the elderly | magnetic resonance imaging | memory | memory impairment | mental health

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