Exposure to high dose estrogens in adolescence: long term effects on mammographic breast density

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/403002

Funding Status
Closed

Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the .

Funded Activity Summary

Breast density is a well established risk factor for breast cancer, and has been shown to be reversibly influenced by hormone exposures in adult life. As one of the important roles of sex hormones during puberty is mammary cell proliferation, it is plausible that exposures at this earlier life stage might have a sustained influence on breast tissue composition and density, and subsequent breast cancer risk. This project aims to increase our understanding of the influence of sex hormones in adolescence on breast cancer risk by testing the hypothesis that exposure to large doses of sex hormones during adolescence has long-term effects on mammographic density. This will be done by comparing the mammographic densities of women who were treated with high doses of estrogen for tall stature during adolescence with women who were similarly assessed for tall stature but not treated. No previous study in humans has examined the long-term effects on breast tissue of high dose estrogen exposure at this early life stage. This is not surprising, given the difficulty in finding a suitable exposed population. This cohort of women, assessed or treated for tall stature, provides us with a unique opportunity to examine these influences. This research will add to our understanding of the influence of sex hormones in adolescence on mammographic density and breast cancer risk. If hormonal factors in adolescence are shown to influence mammographic density, this may lead to new avenues for breast cancer prevention efforts that are targeted much earlier in life. This information may lead to new research directions examining adolescent hormonal exposures (both endogenous and exogenous) and their influence on breast tissue.

Funded Activity Details

Start Date: 01-01-2006

End Date: 01-01-2006

Funding Scheme: NHMRC Project Grants

Funding Amount: $89,050.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Epidemiology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Adolescence | Breast cancer | Cohort study | Mammography | Sex hormones | Tall girls | Women's health

Related Links