Early parenteral nutrition vs. standard care in the critically ill patient: A level I randomised controlled trial.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/402643

Funding Status
Closed

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Funded Activity Summary

Nutritional support is accepted as a standard of care for the hospitalised patient however there is little agreement as to how it should be provided to the critically ill patient. Despite the fact that studies consistently link malnutrition to worse outcomes, the provision of nutritional support to the critically ill patient is highly variable. Although there is general agreement that it is best to feed critically ill patients via the gastrointestinal tract (stomach tube feeding), there is no general agreement as to when intravenous artificial nutrition should be begun if a patient cannot tolerate a feeding tube. A recent systematic review of all available clinical trials suggests that if a critically ill patient cannot be fed by a stomach tube for at least 24 hours, they may benefit from intravenous artificial nutrition. This is not what currently happens under standard care. The purpose of this multi-centre randomised controlled trial is to determine if early intravenous nutrition saves lives. Because of the cost, and possible risk of increased infections, a study of this type is required before early intravenous nutrition could become a routine therapy in Australia. Informed consent to participate in the study will be obtained from next of kin, or directly from the patient themselves. The study will be managed at the Royal North Shore Hospital, University of Sydney and will include 26 collaborating ANZ hospitals over 18 months.

Funded Activity Details

Start Date: 01-01-2006

End Date: 01-01-2008

Funding Scheme: NHMRC Project Grants

Funding Amount: $1,852,333.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Intensive Care

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

clinical research | critical care | critical illness | enteral nutrition | intensive care | nutrition support in critical illness | parenteral nutrition | randomised controlled trial

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