Pathophysiology of malaria-associated lung disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/402450

Funding Status
Closed

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Funded Activity Summary

About 2 million people die each year from complications of malaria infection. A frequent, life-threatening complication of severe malaria is lung oedema. There is no specific treatment for the lung complications, which are poorly understood. There has been until now no good model system to study malaria lung complications. We have developed in mice an experimental model of malaria specifically to determine the mechanisms that cause lung pathology, which has never been done before. Such experiments cannot be performed in humans for ethical and logistical reasons. We believe that pulmonary oedema is caused by products of the immune system and we will rigorously test this idea in our study. The aim is to learn more about the processes occurring in this disease so as to devise new treatment strategies.

Funded Activity Details

Start Date: 01-01-2006

End Date: 01-01-2008

Funding Scheme: NHMRC Project Grants

Funding Amount: $422,517.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Parasitology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

acute respiratory distress syndrome | cytokine | immunopathology | infectious disease | inflammation | lung disease | pulmonary oedema | severe malaria

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