Cohesin dysfunction: potential new route to tumourigenesis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/400207

Funding Status
Closed

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Funded Activity Summary

This proposal aims to investigate the role of a newly-discovered chromosomal and DNA repair protein, Rad21, in breast cancer. Rad21 is a gene, present in many species and essential for accurate chromosome separation. Based on its' known function in different species, it is conceivable that its' dysfunction could fuel cancer progression by promoting genetic instability, eg. gains or losses of chromosomes, commonly associated with human cancers. No definitive data currently exists as regards the potential role of this gene in cancer development. This study is thus the first systematic investigation towards understanding the function of this potential cancer-causing gene. Although the proposed study focuses on breast cancers, it could, in principle, apply to other cancer types in which its' overactivity has recently be oberserved. This study could also have implications for the response of humans to radio- and chemo-therapy for cancer treatment

Funded Activity Details

Start Date: 01-01-2006

End Date: 01-01-2008

Funding Scheme: NHMRC Project Grants

Funding Amount: $386,511.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Oncology and Carcinogenesis

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

DNA repair | breast cancer | carcinogenesis | chromosomal disorders | early tumor detection biomarkers | malignancy | molecular basis of disease | tumourigenesis

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