Predictive significance of tumor hypoxia in patients with head and neck cancer treated on a randomized trial

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/400118

Funding Status
Closed

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Funded Activity Summary

Some patients who receive chemotherapy and radiotherapy for head and neck cancer are not cured because their cancer cells are starved of oxygen that limits the ability of the chemotherapy and radiotherapy to kill the cancer cells. In this research project we will determine if measurement of low oxygen in the cancer will predict response to a novel cancer drug tirapazamine that selectively kills cells that are starved of oxygen. Low oxygen will be assessed by special scans, blood tests and by performing molecular tests on cancer specimens. Success in this project may mean that we can identify patients who will most benefit from this treatment.

Funded Activity Details

Start Date: 01-01-2006

End Date: 01-01-2008

Funding Scheme: NHMRC Project Grants

Funding Amount: $512,931.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Oncology and Carcinogenesis

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Chemo-radiation | Chemotherapy | Head and Neck Cancer | Hypoxia | Positron Emission Tomography | Radiotherapy of Cancer | Randomised controlled trial

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