Deregulation of ribosome signalling, synthesis and function during malignant transformation.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/400116

Funding Status
Closed

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Funded Activity Summary

A major feature of tumour progression is accelerated cell growth and protein synthesis. Moreover, increased synthesis of ribosomes (the protein synthetic machinery) is associated with malignancy suggesting that it may play a causal role in cancer formation. In support of this, specific inhibitors of both ribosome biogenesis and function are extremely effective in inhibiting the growth of some tumours. This study will examine the mechanisms of deregulation of ribosome biogenesis and function during cancer formation and assess for the first time whether aberrant regulation of ribosome biogenesis and function directly contributes to the initiation and-or progression of cancer.

Funded Activity Details

Start Date: 01-01-2006

End Date: 01-01-2008

Funding Scheme: NHMRC Project Grants

Funding Amount: $522,773.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Basic science | Cancer and related disorders | Cell signalling | Control of growth | Intracellular signal transduction | Malignant tumour growth | Novel therapeutics | Protein kinases | Ribosome Biogenesis | Translation

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