A novel mechanism for the regulation of T cell shape and function.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/400043

Funding Status
Closed

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Funded Activity Summary

T cells are a key component of the immune system, and an understanding of their regulation has already lead to important therapeutic interventions. It is now apparent that the shape of the T cell impacts upon its ability to be activated, to migrate through the body, and to kill target cells. We have identified a novel means by which T cell shape is controlled, involving a group of proteins which orchestrate molecular traffic throughout the cell. This project application is to elucidate the mechanisms by which the group of proteins regulates T cell shape and function. We will test whether the proteins act together to integrate signals throughout the entire T cell, and will test whether the proteins influence T cell function in the test tube and in the mouse.

Funded Activity Details

Start Date: 01-01-2006

End Date: 01-01-2008

Funding Scheme: NHMRC Project Grants

Funding Amount: $384,398.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

Cell Biology | Cell polarity | Cell-cell communication | Immune Regulation | Immunology | Protein Trafficking | T lymphocyte Responses | T lymphocytes

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