Seminal plasma cytokines as novel fertility diagnostics in men

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/399106

Funding Status
Closed

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Funded Activity Summary

Infertility and recurrent miscarriage affect 60-80 million couples globally, including 15% of couples in Australia. Current IVF therapy is not successful when the underlying reason for infertility is failure of the maternal tissues to support embryo implantation. We have discovered signaling proteins present in male semen that act in the female reproductive tissues to prepare for embryo implantation and healthy pregnancy. Recently we have identified those proteins and have shown that some men have an imbalance in seminal proteins that leads to immune rejection of the embryo in the female partner. This project aims to develop a new test for male fertility that is based on seminal plasma proteins and independent of existing sperm count tests. Furthermore we will determine whether seminal protein imbalance can result from the �silent� presence of male reproductive tract infection.

Funded Activity Details

Start Date: 01-01-2005

End Date: 01-01-2006

Funding Scheme: NHMRC Development Grants

Funding Amount: $101,000.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Reproduction

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

cytokine | infertility | male reproduction | pregnancy | sperm function testing

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