Structure based drug design of inhibitors of the cholesterol-dependent cytolysins and respiratory syncytial virus fusion

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/395532

Funding Status
Closed

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Funded Activity Summary

The aim of this work is to determine the three-dimensional atomic structures of proteins that play a role in infection by human pathogens. The structures will provide the basis for developing compounds that interfere with the function of these proteins and hence have potential as drugs to fight infection. The proteins being studied are required for the invasion of human tissues by pathogens; one group are toxins produced in bacterial infections such as pneumonia and meningitis while the other proteins to be studied are used by viruses to infect human cells.

Funded Activity Details

Start Date: 01-01-2006

End Date: 01-01-2010

Funding Scheme: Early Career Fellowships

Funding Amount: $377,039.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Biotechnology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Crystallography | Infectious Diseases | Membrane Protiens | Protien Structure | Toxin

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