Production of humanised mouse models for haemoglobin E and 0-thalassaemia

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/384297

Funding Status
Closed

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Funded Activity Summary

The proposed study aims to identify and characterise genes critical to male fertility using two mouse models of infertility: 1) Joey mouse line: an ENU induced model of sperm abnormalities. Following linkage analysis, candidate genes will be selected for sequencing to identify the causal mutation. 2) Ggn knockout mice. The role of the testis-specific gene, Ggn will be characterised through a phenotypic analysis of Ggn knockout mice and a series of expression and biochemical analyses. Both models will be of direct value in the identification of commercially relevant contraceptive targets, as well as furthering our understanding of male reproductive function.

Funded Activity Details

Start Date: 01-01-2006

End Date: 01-01-2010

Funding Scheme: Early Career Fellowships

Funding Amount: $280,693.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Genetics

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

ENU mutagenesis | Male infertility | Male-based contraceptive

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