Signalling to telomeres: mechanisms of action of TGFb

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/384189

Funding Status
Closed

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Funded Activity Summary

Cell lifespan is controlled by the enzyme called telomerase. High telomerase activity makes cell immortal as seen in cancer. We recently show that high telomerase activity can be inhibited by transforming growth factor b (TGFb). This may partly explain why TGFb inhibits cancer and induces cell ageing. This project furthers our investigation into the mechanism(s) by which TGFb inhibits telomerase. We recently noted for the first time that TGFb binds to telomerase gene directly, and this is controlled by another protein called c-myc. This work will determine how telomerase is controlled by a balance between TGFb and c-myc in order to find ways to control telomerase and therefore cancer. We will use a combination of sophisticated techniques of cell molecular biology and biochemistry to pinpoint and target different molecules implicated in the actions of TGFb. This study will serve as an important baseline for more applied research in controlling ageing and cancer from development.

Funded Activity Details

Start Date: 01-01-2006

End Date: 01-01-2008

Funding Scheme: NHMRC Project Grants

Funding Amount: $438,520.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

Ageing | Cancer | Cell Biology | Prevention | Smad | TGFb | cell biology | intracellular signalling

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