Regulation of Angiotensin-Converting Enzyme -2 Expression in Liver Injury

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/384183

Funding Status
Closed

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Funded Activity Summary

Very recent studies suggest Angiotensin-Converting Enzyme-2 (ACE2) a newly discovered enzyme, normally undetectable in the liver is markedly increased in liver disease in both man and rats. We have recently identified human liver cell lines that endogenously express ACE2 giving us a unique opportunity to investigate the function of this enzyme. The aim of the present project is to provide further insights into the role of ACE2 in liver disease by determining the regulation, location and transport of ACE2 in cultured liver cells as well as in rat models of liver injury.

Funded Activity Details

Start Date: 01-01-2006

End Date: 01-01-2008

Funding Scheme: NHMRC Project Grants

Funding Amount: $302,764.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical and Health Sciences

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Angiotensin | Cholestatic Liver disease | Hepatic Fibrosis | Hepatocellular Injury | Renin-angiotensin system | novel mechanisms of liver protection

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