Characterisation of erythropoietic mutants identified in a forward genetic screen in mice.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/382900

Funding Status
Closed

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Funded Activity Summary

The human bone marrow is the pivotal organ in the replacement of the vast numbers of blood cells normally consumed each day. One of the cells regenerated by this organ are the red blood cells which are critical for the transport of oxygen to the tissues. This proposal uses genetically altered mice to identify genes that are critical for the production of normal red blood cells. Mice exposed to a chemical that induces random mutations in their genome are bred and pups with abnormal red blood cells are identified. The responsible genetic mutation is identified and the gene is then studied to determine how it influences red blood cell production. The results of these studies provide insights into a variety of human conditions including anemia, thalassemia and sickle cell disease.

Funded Activity Details

Start Date: 01-01-2006

End Date: 01-01-2009

Funding Scheme: NHMRC Project Grants

Funding Amount: $501,902.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Haematology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

anemia | erythropoiesis | gene mapping | hereditary red cell defects | mutagenesis | sickle cell disease | thalassemia

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