The Role of AS160 in Insulin Action

Funded Activity Summary

Obesity and diabetes are increasing in our community at an alarming rate. When one considers that Diabetes is a major cause of heart disease, stroke and kidney disease these diseases represent one of the most threatening for the future health of our nation. At the heart of these diseases is a disorder known as insulin resistance, or the inability of insulin to function correctly. The explosion in biological outcomes over the past decade has brought us closer than ever before to solving some of the key questions associated with this problem. This proposal represents an exciting step forward in this area because our recent research combined with information from our international colleagues have led us to propose a new concept concerning the mechanism of insulin action. In this proposal we have formulated a series of molecular experiments to test this hypothesis which if correct will both change the way we think about this problem and provide new prospects for therapeutic design.

Funded Activity Details

Start Date: 01-01-2006

End Date: 01-01-2008

Funding Scheme: NHMRC Project Grants

Funding Amount: $505,523.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Cancer | Diabetes mellitus | Glucose transport | Infectious diseases | Insulin resistance | Membrane fusion | Neurological disease | Protein trafficking | SNARE proteins | Vesicle transport

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