Preclinical development of a humanised antibody to C5aR.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/376001

Funding Status
Closed

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Funded Activity Summary

Complement factor C5a is one of the most potent inflammatory mediators in the body. We have developed a monoclonal antibody that blocks the C5a receptor in vitro, and completely shuts down disease in a mouse model of rheumatoid arthritis. We plan to develop this promising new antibody into a potent therapy to treat a range of chronic and acute inflammatory diseases. The antibody has been humanised and this will be tested in three models of inflammation (rheumatoid arthritis, sepsis and colitis) to determine the efficacy of the antibody, safety, the most effective dose, timing and route of administration. These studies are a necessary prelude to human clinical trials, which we hope to perform in approximately 24 months.

Funded Activity Details

Start Date: 01-01-2006

End Date: 01-01-2006

Funding Scheme: NHMRC Development Grants

Funding Amount: $124,875.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Immunology

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

complement C5a | inflammation | monoclonal antibody | rheumatoid arthritis | sepsis

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