Analysis of functional role of the BDNF precursor in sensory neurons

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/375110

Funding Status
Closed

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Funded Activity Summary

Neurotrophins, which are generated from their precursors, are essential for the survival and function of the nervous system. One of neurotrophins, brain derived neurotrophic factor (BDNF), is made in sensory neurons and transported towards nerve terminals. Mutation of a single amino acid in the precursor of BDNF disrupts this transport. This project will examine whether the precursor of BDNF has any function within sensory nerves. We will examine whether the precursor of BDNF gets into the nerve via its receptors and whether it plays any role in the development of pain and maintenance of neuropathic pain after nerve injury. Successful execution of the project will eludicate mechanisms of pain, especially neuropathic pain, and will provide important information to assist in the design of drugs for neurological diseases.

Funded Activity Details

Start Date: 01-01-2006

End Date: 01-01-2008

Funding Scheme: NHMRC Project Grants

Funding Amount: $457,267.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Sensory Systems

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

brain-derived neurotrophic factor | neurological diseases | neuropathic pain | nociception | pain | sensory neurons

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