Mechanically-restricted percutaneous gene therapeutic solutions for heart failure.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/367630

Funding Status
Closed

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Funded Activity Summary

We have developed a novel system for the localized delivery of specialised genes to the heart in order to improve contractility and function of a failing heart. Many genes, for reasons of toxicity, clearance, or uptake, require direct delivery to the target region without spillover to the systemic circulation. Our system addresses these issues by isolating the local circulation of the target organ and directly delivering the agent with minimal systemic loss and improved delivery and uptake efficiency, while minimizing potentially dangerous and toxic systemic effects.

Funded Activity Details

Start Date: 01-01-2005

End Date: 01-01-2006

Funding Scheme: NHMRC Development Grants

Funding Amount: $187,000.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Gene and Molecular Therapy

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Adeno-associated virus | Gene Therapy | Gene delivery | Heart failure | Myocardial contractility

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