Pathogenesis of Persistent Human Virus Infections of Global Significance

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/358399

Funding Status
Closed

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Funded Activity Summary

The study will investigate why humans cannot eradicate particular viruses (HIV-AIDS, cytomegalovirus and herpes simplex virus), the long term effects of these viruses and ways to improve control. Current treatments can only partly suppress the levels of these viruses, because they persist in certain parts of the body called reservoirs, only to resurge later causing disease. Thus, the overall aim of the research program is to discover the mechanisms by which these viruses are able to successfully persist within reservoirs in the human body. The research program brings together a group of 6 leading scientists and clinicians located at 3 sites in 2 Australian cities. The team is comprised of experts in the study of HIV-AIDS, cytomegalovirus and herpes simplex virus who will combine their knowledge and expertise to speed up the process of research on these viruses that are of major health importance. Studies will also utilise a number of cutting edge technologies that now make it possible to much more rapidly and precisely determine how viruses cause disease. Advances in our understanding of how viruses persist may form the basis for treatments aimed at controlling persistent infections and the serious diseases caused by these viruses.

Funded Activity Details

Start Date: 01-01-2005

End Date: 01-01-2009

Funding Scheme: Programs

Funding Amount: $6,571,328.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Virology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

HIV/AIDS, cytomegalovirus, herpes simplex virus | macrophage, dendritic cell | neurobiology, immunology, microarray | viral pathogenesis | viral persistence

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