microRNAs in normal and neoplastic myelopoiesis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/358300

Funding Status
Closed

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Funded Activity Summary

In Australia seventeen persons are diagnosed with leukemia or a related blood disorder each day. An understanding of the way the body controls blood cell production has widespread relevance to diseases like leukemia and the way that they are treated. The burden of this disease on the Australian health budget will continue to increase dramatically as our population ages in coming years. Moreover, an understanding of blood cell production has wider relevance to similar control mechanisms in other organs, as nature reuses its best inventions. Australia has had an enviable international record in discoveries related to factors controlling blood cells and we wish to continue that tradition by examining an exciting new development involving microRNAs. These molecules are found in all normal cells but they have been ignored until recently. Although the field is in its infancy, we now know that these microRNAs are likely to be involved in many cellular processes. In this project we will study the importance of this new class of regulatory molecule in order to discover previously-hidden functions in normal blood cells and their malignant counterparts (leukemias) in humans. The team comprises two laboratories which have collaborated for many years and already a number of exciting molecular methods have been developed. Ultimately this project may lead to novel treatments involving gene therapy, bone marrow transplantation and blood hormones.

Funded Activity Details

Start Date: 01-01-2005

End Date: 01-01-2007

Funding Scheme: NHMRC Project Grants

Funding Amount: $412,500.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Haematology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

anti-cancer drugs | blood | bone marrow | cell differentiation | haemopoiesis | leukaemia | microRNA | myeloid leukaemia | myelopoesis

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