Obesity: The role of Neuropeptide Y, Melanocortin and Serotonin Systems in Development and Prevention

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/354107

Funding Status
Closed

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Funded Activity Summary

This project is about the study of central regulation of energy balance contributing to protection or development of chronic high-energy diet-induced obesity. Obesity is a major predisposing factor for a variety of life threatening diseases such as type II diabetes, hypertension, and coronary heart disease with their enormous costs both socially and financially. Development of human obesity and its related metabolic disorders is a long term process generally develops over a long period and eventually becomes a chronic condition. Generally, chronic consumption of high-energy food in excess of expenditure leads to excessive fat accumulation and promotes the development of obesity. However, studies on both humans and experimental animals have revealed that not all individuals become obese on a high-energy diet; thus, individual susceptibility is an important phenomenon allowing us to search for the genes contributing to the individuals' susceptibility or resistance to diet-induced obesity and to identify for effective targets for both prevention and treatment of obesity. Using the animal models developed in our laboratory, the proposed research aims to demonstrate the differences in the central regulation between the mice resistant or susceptible to the development of chronic high-energy diet-induced obesity. Outcomes of this project will provide us with: 1) better targets for the prevention of diet-induced obesity; (2) more effective treatments for the late stage of obesity and its related metabolic disorders; and (3) a better understanding of the individual susceptibility to diet-induced obesity.

Funded Activity Details

Start Date: 01-01-2005

End Date: 01-01-2007

Funding Scheme: NHMRC Project Grants

Funding Amount: $258,000.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Central Nervous System

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

Brain | Hyperleptinemia, hyperlipidimia and hyperglycemia | Molecular Neurobiology | Neuropeptide | Obesity | Obesity and its related metabolic disorders | Regulation of energy intake | Treatment of chronic high-energy diet-induced obesity | mRNA expression

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