Pathophysiological correlates in smokers and smoking-related Chronic Obstructive Pulmonary Disease (COPD)

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/352609

Funding Status
Closed

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Funded Activity Summary

Smoking-related chronic airway narrowing (COPD) is a common and major illness. Research on the characteristics of the actual pathological process in the airways in smokers and COPD using direct tissue sample is relatively new. Data is currently limited and rather contradictory. In this grant we will recruit a spectrum of smokers and COPD patients typical of those in the Australian community and will be undertaking a detailed analysis of the cellular and some vascular structural changes in the airway wall. Both cellular and vascular changes will be related to the fixed and reversible component of airway obstruction. Reversible changes with smoking cessation will be studied. A very novel feature will be a preliminary assessment of the utility of proteomics for assessment of airway pathology.

Funded Activity Details

Start Date: 01-01-2005

End Date: 01-01-2007

Funding Scheme: NHMRC Project Grants

Funding Amount: $283,500.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Respiratory Diseases

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Airway inflammation | Airway remodeling | Bronchodilator responsiveness | COPD | COPD pathophysiology | Smoking | Smoking-related diseases

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