Co-administration of DNA encoding co-stimulatory molecules enhances the efficacy of immune response to foreign antigen

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/351556

Funding Status
Closed

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Funded Activity Summary

Vaccines to prevent or treat infectious diseases and some cancers are urgently needed. Infected cells and some cancer cells display unique proteins which the body's immune system can recognises as 'foreign'. The body will then mount an immune response, which, if successful, will eradicate the infected or cancerous cells. Dendritic cells (DCs) initiate the body's immune response by instructing other immune cells to mount a response. For a vaccine to be successful it is important that the vaccine activates the DCs in the right way. We propose to activate DCs by vaccinating with DNA encoding recently identified costimulatory molecules, as well as DNA encoding the foreign antigen. Our earlier work leads us to believe that this will enhance the immune response, and lead to a more effective state of immunity

Funded Activity Details

Start Date: 01-01-2005

End Date: 01-01-2006

Funding Scheme: NHMRC Project Grants

Funding Amount: $182,000.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Immunology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Cytotoxic T cell | DNA vaccine | HPV | costimulatory molecule | dendritic cell | dendritic cells | immune protection | immunity cellular | vaccine vectors

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