Generation of Complex Responses in Retinal Ganglion Cells

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/351538

Funding Status
Closed

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Funded Activity Summary

The retinal ganglion cells, whose axons form the optic nerve, comprise numerous distinct types, which respond to visual stimuli in either a simple or complex manner. The project will investigate how the complex responses of the direction-selective ganglion cells (DSGCs) and the local-edge-detector ganglion cells (LEDs) are generated. It appears that the retinal neurons providing inhibitory input to DSGCs and LEDs use different neurotransmitters, and the project will investigate how this shapes the response properties of the ganglion cells. This will be done both by recording the visually evoked responses of the ganglion cells in an isolated preparation of the retina and by using two-photon laser-scanning microscopy to functionally image the neuronal interactions between the neurons that inhibit the DSGCs.

Funded Activity Details

Start Date: 01-01-2005

End Date: 01-01-2007

Funding Scheme: NHMRC Project Grants

Funding Amount: $490,500.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Sensory Systems

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

CNS function | central nervous system | neuroanatomical connections | neuroanatomy | neurophysiology | neurotransmission | retina | retinal function

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