Preserving Junctions: regulating cadherins by Rho and Myosin 2.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/351447

Funding Status
Closed

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Funded Activity Summary

This project studies the molecular mechanisms responsible for holding cells together in normal tissues. Such cell-to-cell adhesion is mediated by the cadherin family of molecules, which reside at the surfaces of cells. Cadherins allow cells to recognize one another and, upon recognition, adhere to one another. By this means populations of individual cells can be linked together into cohesive populations (i.e. the tissues or organs of the body). The importance of cadherin adhesion is exemplified by the well-documented observation that disruption of cadherin adhesion contributes to many important diseases, including inflammation of epithelia and cancers. Thus understanding the mechanisms by which cadherins hold cells together is necessary for us to understand the molecular basis of commondisease. Characteristically, cadherins accumulate in structures called adherens junctions, and preserving those junctions is important both for tissues to organize and also to prevent tumor progression. Despite this, we know very little about how junctions are preserved in epithelia. The research to be conducted in this grant will examine exactly this problem. It builds upon recent findings from my lab which indicate that the motor molecule, myosin 2 plays an essential role in preserving junctions. Furthermore, we will test the role for signaling pathways within cells to control the activity of myosin 2 at junctions. This research will provide important novel insights into the cellular mechanisms that couple cells into tissues, and how they may be disrupted in diesase.

Funded Activity Details

Start Date: 01-01-2005

End Date: 01-01-2007

Funding Scheme: NHMRC Project Grants

Funding Amount: $425,500.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Interactions (incl. Adhesion, Matrix, Cell Wall)

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

Actin cytoskeleton | Cadherin adhesion molecules | Cancer | Epithelial inflammation | Epithelial morphogenesis | Gastrointestinal disease | Kidney disease | Myosin

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