Muller cell reactivity during diabetic retinopathy

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/350434

Funding Status
Closed

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Funded Activity Summary

Diabetes is the leading cause of blindness in the working population. In some patients with diabetes, blood vessels within the retina proliferate, haemorrhage or cause retinal detachment. The underlying changes within the retina that lead to the proliferation of blood vessels are not well understood. One of the factors that leads to changes in retinal blood vessels is an increase in growth factors from cells within the retina called Muller cells. Muller cells are vital for the normal function of the retina and are known to be abnormal late in diabetes. They may also be dysfunctional early in diabetes and could play a significant role in causing the early changes seen in diabetes. Therefore a good understanding of how Muller cells change and the time at which they change is vitally important to gain a better understanding of the defects that are associated with diabetes. Furthermore, an understanding of the basic underlying cellular changes that occur in dibaetes will aid the development of more specific therapeutic agents in the future.

Funded Activity Details

Start Date: 01-01-2005

End Date: 01-01-2007

Funding Scheme: NHMRC Project Grants

Funding Amount: $258,000.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Sensory Systems

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Diabetes | Diabetic retinoopathy | Glial-vascular interaction | Muller cell | Purinergic receptors | Retina | hyperglycaemia | ischaemia

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